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Marios Kyriazis

Exploring the Frontiers of Anti-Aging Medicine:
An Interview with Dr. Marios Kyriazis

By David Jay Brown

Marios Kyriazis, M.D. is both a clinician and a researcher in the field of anti-aging medicine.  He has made significant contributions in the science and application of anti-aging medicine, and he is considered one of Britain’s leading longevity specialists. Dr. Kyriazis is one of the world’s experts on the subject of how carnosine effects the aging process, and his research into the effects of this mighty amino acid dipeptide have revealed how it can offer a number of unique and substantial health benefits.

Dr. Kyriazis has a postgraduate degree in Gerontology from the King’s College, University of London, and another in Geriatric Medicine, granted by the Royal College of Physicians. He is also a Chartered Biologist, and a Member of the Institute of Biology for his work in the biology of aging. Dr. Kyriazis is the founder and medical advisor to the British Longevity Society, and he is a certified member of the American Academy of Anti-Aging Medicine. He is also an adviser to several other age-related organizations.

Dr. Kyriazis has extensive experience with nutritional supplements and anti-aging drugs. He is the author of several books on these subjects, including The Anti-Aging PlanStay Young Longer–NaturallyThe Anti-Aging CookbookThe Look Young Bible, and Carnosine And Other Elixirs Of Youth.
Dr. Kyriazis lives Hertfordshire, England. I interviewed him on November 6, 2004. Dr. Kyriazis has a warm and thoughtful manner about him. We spoke about the best ways to slow down the aging process, his research and clinical experience with carnosine, and how just the right amount of stress can actually benefit our health.

David: What do you think are the primary causes of aging?
Dr. Kyriazis: When I think about the primary causes of aging I divide them into two groups–fifty percent genetic and fifty percent environmental. From the environment we get free radicals, glycosylation, and hormonal changes. At the moment I don’t think there is anything that we can do about the genetic part, but we can of course influence the environmental part of aging. So I am working in clinical medicine to offer ways of counteracting the environmental causes, or the environmental basis of aging.

David: How do you differentiate between the biological symptoms of aging and those bodily changes that are actually caused by one’s belief about aging?

Dr. Kyriazis: It depends at what level one looks. I am more interested in the clinical level, although I have done biological research as well. I think there are different ways of looking at it. Biology will start with the molecules and the cells, and say this is an age-related phenomenon, a disease-related phenomenon. From my point of view I see individual patients. People usually come to see me because they have an age-related illness. So they come with, say, heart disease, or a prostate problem, which are age-related. Then when we expand on the actual causes of their problem they want to know more and find out about other age-related processes which may affect them. So it is a combined thing. I don’t necessarily make a distinction myself in my work.

David: What do you think are currently the best ways to slow down, or reverse, the aging process and extend the human life span?

Dr. Kyriazis: I offer a combination of different therapies affecting the entire body. For example, I recommend antioxidants and anti-glycator drugs or supplements. Apart from the ordinary vitamins and nutrients, I recommend carnosine, DHEA, and other hormones, depending upon whether the individual is deficient in those hormones or not. I also recommend a  nutritional lifestyle and exercise–but not ordinary exercise. It’s a combination of different unusual exercises (which I discuss in my book The Anti-Aging Plan) plus mental and sense exercises as well.

I try to make it easy for the individual to follow this, because many times people think that it’s much easier to just take a tablet or a capsule, rather than change their lifestyle. But I think it is very important to find a way to motivate the individual to change their lifestyle. So, in other words, it’s a combination approach. Different things all working together. Some people say, oh take four different supplements, or four different hormones, and you are covered. I don’t agree with that. I think that there are so many different aspects of aging, and that we need to use different treatments, a multi-pronged approach. So that’s what I say to my patients.

David: Can you talk a little about some of the beneficial effects your patients have had with carnosine supplements?

Dr. Kyriazis: Yes. I think I was the first person to use carnosine for anti-aging purposes. Carnosine has been around for quite some time, and athletes used to use it to enhance muscle and a performance. But I began using it specifically for anti-aging back in 1999. And the first person who took carnosine under my guidance still takes it today, five years later, and everyone says how young she looks generally. Her head hasn’t got a single grey hair–not one–although she’s now 48 or 49. This corresponds with experiences we have had with other patients. In other words, they generally look younger. Their hair grows better, and it stays black, or whatever color it is, but not grey. Many people experience increased energy. Mental performance, memory, and other brain functions improve as well.

But I always say to people that carnosine is not something that you can notice yourself. It’s something that works inside the body over the long-term, over ten or twenty years to prevent all the different age-related processes and damages that happen. I see carnosine mainly as a preventative treatment, not so much as an immediate treatment for some specific disorder, or to be noticeable. It doesn’t immediately produce noticeable effects, although there are ways of doing different biochemical tests, blood tests, and so on, that show an overall improvement over the years.

I use carnosine on patients who are normally healthy, who don’t have a disease. For example, I don’t use it on people who have muscular dystrophy or other muscular diseases. I think some people take it for that, but I don’t know whether it works or not. So it is difficult to differentiate and see a noticeable improvement on a healthy person. It’s much easier to notice if somebody is ill and he or she gets better after taking it. But this supplement is mainly used by healthy people in the long-term.
David: Can you talk a little about carnosine’s anti-glycosylation effect, and how it protects the body from dangerous cross-linked, oxidized proteins?

Dr. Kyriazis: Everybody thinks that free radicals and oxidation are the main causes of aging, but there’s another important one, which is glycosylation, and this happens all the time. It is due to glucose or other molecules attaching to proteins. This causes cross-linking and “advanced glycosylation end-products” or AGEs. I would say that this causes more damage to the body than free radicals, and carnosine prevents this damage in different ways.

First of all, it prevents free radical attacks because it’s an antioxidant. But it is also an anti-glycosylator. In other words, it prevents the proteins from being cross-linked. If two proteins that are not supposed to attach to each other, become attached and combine together, then they become useless. That’s what happens in cross-linking, and carnosine prevents that. Carnosine is like a shield that protects proteins. So when two proteins come together they don’t attach to each other. They remain free to function normally.

So the first stage is that carnosine prevents glycosylation in the first place. The second stage is that if glycosylation has already happened, if the two proteins have become cross-linked, carnosine will facilitate the removal of these useless proteins. Actually, our body is trying to eliminate abnormal proteins all the time, but with aging this rate of elimination slows down. Therefore we have an accumulation of abnormal proteins. But carnosine speeds up the rate of elimination, so all the junk material we have in our body gets eliminated quicker.

There is also some evidence that carnosine can actually break the existing bonds between the two cross-linked proteins. So if the proteins have become attached to each other, and they are cross-linked, in some circumstances carnosine can break the bond and allow them to be free again, and to function normally. So carnosine has three different benefits in addition to being an antioxidant.

David: What kind of dosage do you recommend  a healthy person take?

Dr. Kyriazis: I started with fifty milligrams a day, but now I recommend a higher dose–perhaps about two hundred milligrams a day. I know that some people use a thousand or more milligrams a day, but I don’t see the reason for that. I think about two hundred milligrams a day, in association with other supplements, should be enough for a healthy person.
David: What are your thoughts about using N-Acetylcarnosine eye drops–which breakdown into carnosine in the eye–as a way to protect the health of one’s eyes?

Dr. Kyriazis: This is also a very promising development. I was involved with advising the different researchers at the companies that are now marketing acetylcarnosine. The things that carnosine does as a tablet doesn’t work as well as

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