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Exploring the New Prosexual Drugs &
the Art of Feeling Really Good

by David Jay Brown

Like immortality and the fountain of eternal youth, every culture since the beginning of time has sought out aphrodisiacs and methods for enhancing the sexual experience. Biological organisms like us seem to find sex and drug ingestion fairly irresistible because these activities activate ancient pleasure centers in our brains. Our ancestors discovered long ago that by combining these two biochemical art forms new dimensions in the realm of “feeling really good” can be achieved. For example, although alcohol intoxication actually interferes with sexual functioning, many people have their first sexual experiences while drunk as a teenager, due to its disinhibiting properties. Maybe not knowing much about history or biology is fine when love is in the air, but knowing your chemistry sure can be helpful in making this a more wonderful world.

Marijuana is a very erotic plant, and the majority of High Times readers are, I’m sure, hip to the fact that if you smoke cannabis prior to sex, every sensation becomes greatly enhanced because it increases the sensitivity of one’s senses. The sensual photo profiles and centerfolds in High Times of the plant itself reflect this erotic quality, as they are clearly modeled after the pictorials of beautiful nude women in Playboy and Penthouse. And as the infamous Playboy interview with Timothy Leary during the Sixties made clear, the popularity of LSD is partially due to acid’s ability to turn sexual activity into a full-blown ecstatic mystical experience. So sex and drugs have always had an intimate relationship, but true aphrodisiacs– substances that actually ignite the feelings of sexual passion– have always just been a myth– conjuring up images of those ridiculous “Spanish fly” ads in the back of sleazy magazines– right?

Maybe not. Contemporary neuroscience research is leading many people to question that assumption, and the beacon of modern pharmacology has created a whole new class of chemical tools to explore this ancient neurochemical connection. On a medical level, effective chemical treatments for such age-old problems as impotence, premature ejaculation, loss of interest in sex, as well as difficulty achieving erection, sufficient lubrication, and orgasm are now available. There is also a variety of chemical means to increase one’s physical sensitivity and subjective enjoyment of the sexual experience. These substances can be used to help make disabled people healthier, and they can also be used by erotic engineers to make great sex even better. Most significantly, there are now chemicals available that appear to actually make you horny.

John Morgenthaler, co-author of Smart Drugs and Nutrients, recently published a new book– Better Sex Through Chemistry(with Dan Joy)– which reveals how to safely enhance one’s sex life through nutrients and a new class of pharmaceuticals which they call “prosexual drugs”. In conversation with Morgenthaler he told me that in researching the book they started “by doing computer searches of Medline and Embase. These are the largest medical science databases in the world with millions of scientific abstracts. We searched on key words like “impotence” and “aphrodisiac” and to our surprise, we downloaded nearly 15 megabytes of data directly related to prosexual enhancement. This is a huge body of scientific work. We had no idea there would be that much substantial information.”

Morgenthaler coined the term “smart drugs” and played a significant role increasing awareness about them. In writing this book he has now made public another popular underground phenomena– which has been picked up on recently by the mainstream media– letting the pussy out of the bag, but providing an extremely valuable resource, which overflows with otherwise obscure hard-to-find information. The media’s recent attention to the subject has got some people, at least in California, somewhat nervous that the FDA or DEA will crackdown on the usage of prosexual drugs, just as they did with smart drugs and MDMA once their popularity began to increase, and they hit the mainstream. But the chemical revolution currently in motion is not taking place exhibitionistically this time at Raves or in dance halls, rather it is occurring discretely in the bedroom. There are now over a dozen important and fascinating nutrients and pharmaceuticals of interest to sexual enthusiasts and biochemical gourmets which are currently available. Some of the most significant of these are discussed below, and I tested a number of them myself in writing this article. (About myself: I’m 34 years old and sexually healthy. My sex drive tends to run higher than most men I know my age, and the only times that I’ve ever encountered any sexual problems is when I’ve been nervous, chemically altered, or overextended.)

Smart drugs and prosexual drugs have a lot in common. As in the case with the majority of smart drugs, all of the major substances discussed in this article share exceptionally low levels of toxicity, and they are all legal. Some of the prosexual substances, such as deprenyl and bromocriptine have also been shown to increase intelligence, booster attention, and benefit memory consolidation. Inversely, some of the smart drugs such as piracetam and vasopressin have been reported to have sexually beneficial effects. According to gerontologist and life extension researcher Ward Dean, M.D., “…anything that improves brain function is probably going to improve sexual functioning.”

All of the prosexual substances discussed in this article are also extremely safe, remarkably free of side-effects, non-addictive, and in general improve overall health. This would have to be the case with any substance that improved sexual vitality over an extended period of time, as sex and health are intimately linked. So great is their connection that a healthy sex life is one of the primary indicators of overall good physical health. In fact, Morgenthaler told me that he is “really much more interested in health and longevity than sexual enhancement. For me, this was a way of writing a life extension book that would sell. We are using sex as the hook to sell life extension.” Better sex, I’ll admit, certainly provides me with additional motivation to want to live a longer and healthier life.

It has long been known that proper nutrition is essential for maintaining the desire, capacity, and stamina necessary for a healthy sex life. Many nutrients and amino acids play vital roles in facilitating the process of neurotransmission and/or bloodflow in regions of the brain and genitals which are responsible for sexual function and sensation. Taking supplements can sometimes be beneficial. For example, L-Arginine– an essential amino acid readily available in most health food stores– has been shown to increase the ability to obtain erections and maintain stamina, as well as overall increasing libido, and is reported to also increase the intensity of sexual sensations.

This effect is due to the fact that L-Arginine increases the production of an excitatory neurotransmitter called NO (nitric oxide, the only known gaseous neurotransmitter), which is widely recognized as the sole chemical responsible for causing penile erections. Although less studied in women, one 21 year old female taking L-Arginine supplements has been quoted as saying, “My god, that stuff! I had to stop taking it. I was doing it with every guy that came along.” (Could this be what Nancy Reagon meant by “Just say NO.”?) So I tried the stuff. My research notes for L-Arginine read as follows:

10:30 am: I swallow two teaspoons of “ProSexual Plus”, a passion-fruit flavored cocktail with 3 grams of L-Arginine, some ginko baloba, along with other vitamins and nutrients packed into it. It tastes pretty good. My research partner says “no thanks”, and doesn’t want to try it. 11:45: Feeling horny for sure, but also a bit edgy and anxious. Kissing and cuddling with my partner is exquisite, but no more so than usual I don’t think. No problem getting an erection, but this hasn’t been a problem. 12:00: Smoke some grass, which helps to reduce some of the edginess, and allow me to more enjoy the heightened sexual desire. Entering my partner is divine, but not significantly different from the night before. 12:20: Climax is powerful, although not significantly enhanced or altered. 2:00: Still feel energized and slighly anxious, although less so.

Niacin, or vitamin B-3, when taken on an empty stomach causes blood vessels near the skin to dilate for several minutes, which produces the well-known “niacin flush.” Sexual activity also causes the skin to flush, through the natural release of histamines. Taking niacin prior to sex, many claim, increases tactile sensations, electrifying the sense of touch, and enhancing orgasms. The niacin rush feels prickly and uncomfortable for me in general, but during sex the flood of histamines seems to feel warm and make me glow. This stuff is certainly worth trying. Many people swear by it and it’s very popular. Niacin is inexpensive and available in every vitamin store and

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