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Antioxidants Extend Life

metabolites, such as acetyl carnitine and lipoic acid. This restores mitochondrial function to a large extent after just a few weeks. It also lowers oxidants to the level of a young rat and increases ambulatory activity. It’s really amazing. They become lively old rats. They get up and do the macarena. I’d like to get that into people.”


* Reactive oxygen species are the entire class of highly reactive molecules derived from the metabolism of oxygen. Scientific interest in reactive oxygen species and oxidative stress is growing very rapidly. A Medline search on these terms brings up 177 citations between 1976 and 1984. Between 1996 and the present, the figure increased to 5,756.4



  1. Taub J, Lau JF, Ma C, Hahn JH, Hoque R, Rothblatt J, Chalfie M. A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. Nature May 1999;399:162-6.
  2. Beckman K, Ames B. The free radical theory of aging matures. Physiolog Rev April 1998;78(2):547-81.
  3. Ames B. Micronutrients prevent cancer and delay aging. Toxicol Lett 1998;102-103:5-18.
  4. Gilbert D, Colton C, eds. Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach.Plenum, New York, 1999.

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